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Dysregulation of lung tissue collagen level plays a vital role in understanding how lung diseases progress. However, traditional scoring methods rely on manual histopathological examination introducing subjectivity and inconsistency into the assessment process. These methods are further hampered by inter-observer variability, lack of quantification, and their time-consuming nature. To mitigate these drawbacks, we propose a machine learning-driven framework for automated scoring of lung collagen content. Our study begins with the collection of a lung slide image dataset from adult female mice using second harmonic generation (SHG) microscopy. In our proposed approach, first, we manually extracted features based on the 46 statistical parameters of fibrillar collagen. Subsequently, we pre-processed the images and utilized a pre-trained VGG16 model to uncover hidden features from pre-processed images. We then combined both image and statistical features to train various machine learning and deep neural network models for classification tasks. We employed advanced unsupervised techniques like K-means, principal component analysis (PCA), t-distributed stochastic neighbour embedding (t-SNE), and uniform manifold approximation and projection (UMAP) to conduct thorough image analysis for lung collagen content. Also, the evaluation of the trained models using the collagen data includes both binary and multi-label classification to predict lung cancer in a urethane-induced mouse model. Experimental validation of our proposed approach demonstrates promising results. We obtained an average accuracy of 83% and an area under the receiver operating characteristic curve (ROC AUC) values of 0.96 through the use of a support vector machine (SVM) model for binary categorization tasks. For multi-label classification tasks, to quantify the structural alteration of collagen, we attained an average accuracy of 73% and ROC AUC values of 1.0, 0.38, 0.95, and 0.86 for control, baseline, treatment_1, and treatment_2 groups, respectively. Our findings provide significant potential for enhancing diagnostic accuracy, understanding disease mechanisms, and improving clinical practice using machine learning and deep learning models. 

Identification and quantitative understanding of factors that influence occupant energy behavior and thermal state during the design phase are critical in supporting effective energy-efficient design. To achieve this, immersive virtual environments (IVEs) have recently shown potential as a tool to simulate occupant energy behaviors and collect context-dependent behavior data for buildings under design. On the other hand, prior models of occupant energy behaviors and thermal states used correlation-based approaches, which failed to capture the underlying causal interactions between the influencing factors and hence were unable to uncover the true causing factors. Therefore, in this study, the authors investigate the applicability of causal inference for identifying the causing factors of occupant/participant energy behavioral intentions and their thermal states in IVE condition and compare those results with the baseline in-situ condition. The energy behavioral intentions here are a proximal antecedent of actual energy behaviors. A set of experiments involving 72 human subjects were performed through the use of a head-mounted device (HMD) in a climate chamber. The subjects were exposed to three different step temperatures (cool, neutral, warm) under an IVE and a baseline in-situ condition. Participants' individual factors, behavioral factors, skin temperatures, virtual experience factors, thermal states (sensation, acceptability, comfort), and energy behavioral intentions were collected during the experiments. Structural causal models were learnt from data using the elicitation method in conjunction with the PC-Stable algorithm. The findings show that the causal inference framework is a potentially effective method for identifying causing factors of thermal states and energy behavioral intentions as well as quantifying their causal effects. In addition, the study shows that in IVE experiments, the participants' virtual experience factors such as their immersion, presence, and cybersickness were not the causing factors of thermal states and energy behavioral intentions. Furthermore, the study suggests that participants' behavioral factors such as their attitudes toward energy conservation and perceived behavioral control to conserve energy were the causing factors of their energy behavioral intentions. Also, the indoor temperature was a causing factor of general thermal sensation and overall skin temperature. The paper also discusses other findings, including discrepancies, limitations of the study, and recommendations for future studies. 

Building performance models (BPMs) are often used to estimate, analyze, and understand the performance of future or non-existing buildings during designs. However, performance gaps between prediction from BPMs and actual building still exist. Obviously, occupant behaviors are one of the major factors which cause the performance gaps because of several reasons, including (1) they are dynamic, (2) they are driven by many contextual factors, and (3) they are difficult to be captured by traditional experiments. This paper discusses a framework of applying generative adversarial networks (GANs) as an alternative approach to combine existing BPMs with occupant responses to design specific and context sensitive factors obtained from immersive virtual environment (IVE) toward designed buildings (target buildings) in order to reduce performance gaps between prediction during designs and actual buildings. 

Building performance discrepancies between building design and operation are one of the causes that lead many new designs fail to achieve their goals and objectives. A main factor contributing to the discrepancy is occupant behaviors. Occupants responding to a new design are influenced by several factors. Existing building performance models (BPMs) ignore or partially address those factors (called contextual factors) while developing BPMs. To potentially reduce the discrepancies and improve the prediction accuracy of BPMs, this paper proposes a computational framework for learning mixture models by using Generative Adversarial Networks (GANs) that appropriately combining existing BPMs with knowledge on occupant behaviors to contextual factors in new designs. Immersive virtual environments (IVEs) experiments are used to acquire data on such behaviors. Performance targets are used to guide appropriate combination of existing BPMs with knowledge on occupant behaviors. The resulting model obtained is called an augmented BPM. Two different experiments related to occupants lighting behaviors are shown as case study. The results reveal that augmented BPMs significantly outperformed existing BPMs with respect to achieving specified performance targets. The case study confirmed the potential of the computational framework for improving prediction accuracy of BPMs during design.